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Zygosity is a way of describing the genetic content at a specific location (locus) on both chromosomes of a specific chromosome pair. Our zygosity testing for transgenic models is done using hydrolysis probes to quantitatively determine if samples are homozygous or hemizygous for the transgene of interest. This differs from standard genotyping which only reports qualitative results (presence/absence). This whitepaper discusses how zygosity is determined for targeted mutations vs. transgenes.
GTCA provides genetic testing and colony management services that support fast and efficient scientific discovery.
